![]() ![]() The drug substance must not recrystallize and/or change its polymorphic form during storage.All the doses dispensed from a given multi-dose container should have acceptable uniformity of drug content.Suspensions must not be too viscous to pour freely from a bottle or to flow through a needle syringe (for injectable suspensions).The product must remain sufficiently homogenous for at least the period between shaking the container and removing the required amount.Suspended particles should be small and uniformly sized in order to give a smooth, elegant product free from a gritty texture.Pharmaceutical suspension should be aesthetically pleasing and should also have a pleasing odour, and taste. ![]() The final product should be physically, chemically and microbiologically stable.Classification of suspension based on the size of solid particles Classification of suspension based on electrokinetic nature of solid particles Classification of suspension based on the concentration of the dispersed phase Parenteral suspension/ injectable suspensions Externally applied suspension/ Topical suspensions Classification of suspension based on the route of administration (general classes) 1 Ideal features of suspension dosage form.Generally, this type of product is a powder mixture containing the drug and suitable suspending and dispersing agents to be diluted and agitated with a specified quantity of vehicle, most often purified water. Other preparations are available as dry powders intended for reconstitution just before use with an appropriate vehicle. Some suspensions are available in a ready-to-use form that is, already distributed through a liquid vehicle with or without stabilizers and other additives. Suspension dosage forms are given by the oral route, injected intramuscularly or subcutaneously, instilled intranasally, inhaled into the lungs, applied to the skin as topical preparations, or used for ophthalmic or otic purposes in the eye or ear, respectively. This, however, is practically not possible because of the thermodynamic instability of suspension. Here, every dose from the suspension will contain the same amount of drug and will give the same clinical effect to the patient. In an ideal suspension, insoluble particulate matter or drugs are uniformly suspended in three dimensions throughout the vehicle and remain so even after prolonged periods of time. Suspensions are not optically clear and will appear cloudy unless the size of the particles is within the colloidal range. Unfortunately, pharmaceutical suspensions fall across the borderline between colloidal and coarse dispersions, with solid particles generally in the range of 0.1 to 10 micrometre. For this reason, a distinction is usually made between a colloid or colloidal suspension with a particle size range of up to about 1 micron, and a ‘coarse dispersion’ with larger particles. However, the particle size of the solid material can affect both its physicochemical behaviour of suspensions. Technically, the term suspension describes a dispersion of a solid material (the dispersed phase) in a liquid (the continuous phase) without reference to the particle size of the solid material. Read Also: How to Reconstitute Oral Suspensions Such drugs are most frequently supplied as dry powder for reconstitution at the time of dispensing. Also, it is an ideal dosage form for drugs that are unstable in an aqueous medium for extended periods of time. This dosage form is used for providing a liquid dosage form for insoluble or poorly soluble drugs. Pharmaceutical suspensions are liquid dosage forms containing finely divided insoluble materials (the suspensoid) distributed somewhat uniformly throughout the suspending medium (suspending vehicle) in which the drug exhibits a minimum degree of solubility. Now all of a sudden it Only shows up in a totally different state and with exact name search. Is there something I could do to send signals to Google to show that I am in Matthews, NC?Ģ months ago my listing quit showing up at all unless you typed exact business name What could possibly cause my listing or Google to do this? I have been without my listing for a few months now and have NO calls coming in from it. If you search Locksmith Independence, KS it shows up on the maps. If you search Locksmith Matthews, NC my listing does not show up at all. Keep in mind the GMB is in Matthews, NC All my service areas and the actual map show the correct areas. Now if I search my business name under the auto populate I see it with Independence, KS on the listing. I pretty much do not have any traffic, views or calls now. Posted about my SAB listing a few weeks ago about not showing up in search only when you entered the exact name. ![]()
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